Activated Vγ9Vδ2 T Cells Trigger Granulocyte Functions via MCP-2 Release

Granulocyte Functions via MCP - 2 Release 2 T Cells Trigger

CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells.

Human Vγ9Vδ2 T cells exert potent in vitro and in vivo antitumor activities, making them promising candidates for immunotherapy strategies. Recognition of tumor cells by Vγ9Vδ2 T cells requires engagement of the TCR and/or NK receptors. Recently, one of the novel NK receptors, the class I-restricted T cell-associated molecule (CRTAM), has been described to promote cytotoxic function of NK cells...

Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells

Activated hepatic stellate cells (aHSCs) are now established as a central driver of fibrosis in human liver injury. In the presence of chronic or repeated injury, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can occur, so there is interest in down-regulating aHSCs activity in order to treat these diseases. Here, we report that Vγ9Vδ2 T cells are reduced in patients with liver cirrhos...

HIV Infection of Monocytes-Derived Dendritic Cells Inhibits Vγ9Vδ2 T Cells Functions

DCs act as sentinel cells against incoming pathogens and represent the most potent antigen presenting cells, having the unique capability to prime naïve T cells. In addition to their role in induction of adaptive immune responses, DC are also able to activate innate cells as γδ T cells; in particular, a reciprocal crosstalk between DC and γδ T cells was demonstrated. However, whether HIV infect...

Role of Vγ9Vδ2+ γδ T cells in juvenile idiopathic arthritis

Patients and methods Mononuclear cells (MC) isolated from synovial fluids (SF) of 47 patients with monoarticular (M, n = 11), pauciarticular (P, n = 19), extended (E, n = 5), polyarticular (Po, n = 2), systemic (S, n = 4), psoriatic (Ps, n = 4), enthesitis related (Sp, n = 2) JIA were dually stained with monoclonal antibodies to CD3 and variable (V) regions of the γδ TCR. Flow cytometry of fres...